At 8.40pm on Monday the Greater Manchester Fire and Rescue Service (GMFRS) received reports of a fire involving a building and a vehicle trailer in a loading area at the centre on Beal Lane in Shaw.
Three fire engines from Rochdale, Oldham and Chadderton attended the scene.
It took fire crews just under three hours to bring the blaze under control.
A spokesperson for the GMFRS said: “At 8:40pm last night we received a report about a fire at a commercial premises on Beal Lane, Shaw, involving a building and a vehicle trailer in a loading area.
“Three fire engines from Rochdale, Oldham and Chadderton were quickly at the scene, and firefighters wearing breathing apparatus used two hose reels and other equipment to extinguish the fire, ventilate smoke from the premises and make the area safe.
“Crews were in attendance for just under three hours.”
The Very Group was based at the distribution centre up until 2021, and at one point employed 1,200 people at the site.
The remaining business, Yodel, has announced it is set to relocate its operations away from the distribution centre.
Oldham councillors have been told the company will have left the Linney Lane site by 2024 and proposals to demolish Shaw Distribution Centre and turn the site into a housing estate are being considered.